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This type of medicine is the most commonly prescribed drug for pain in the world. They are good for treating mild-moderate pain. They work by stopping some of the chemicals produced by the body which irritate nerve endings. Most of these irritating chemicals have other important uses in various places like heart, kidneys or stomach, and in healing damage to the body. For this reason there can be good and bad effects when using these medicines. Most of us will have heard about or even experienced the stomach irritation caused, but we’ve realised more about these medicines in the past ten years. Its been shown that they can also worsen blood pressure and increase strokes or heart attacks in people who are at risk. GPs know this and are far more careful about who gets these type of medicines. Even when buying these medicines over the counter the comments on the packaging suggest if symptoms don’t settle then it’s best to discuss with your doctor. He or she can then assess whether you are at risk of problems and if you need a different way to manage your pain.